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The NZ Government has published a discussion document outlining an Action Plan for the Smokefree Aotearoa 2025 goal and has invited submissions on its proposals. This blog is one of a series examining key aspects of the plan to help inform the debate and submissions. Here we examine the proposal to reduce the nicotine in smoked tobacco products to very low levels. We conclude this strategy is likely to have a profound impact on smoking prevalence and, if implemented as part of a comprehensive plan, gives a realistic prospect of achieving a Smokefree Aotearoa.  

Why reduce nicotine to very low levels?

The action plan proposes reducing nicotine in smoked tobacco products to very low levels and mandating that these are the only smoked tobacco products available for sale in New Zealand. This innovative policy could profoundly reduce smoking uptake by adolescents and young people by minimising the risk that young people who experiment with smoking become addicted to nicotine. It could also prompt and support people who smoke to quit, and decrease relapse among people who, having quit smoking, occasionally smoke a cigarette.1-3 It aligns with the 2010 Māori Affairs Select Committee inquiry findings which recommended reducing the additives and nicotine in tobacco as one of the measures to help achieve the proposed Smokefree 2025 goal.4

What are the arguments and evidence in support of this proposal?

This measure tackles a major gap in the current regulatory regime for tobacco products:  that the design and constituents of smoked tobacco products are unregulated, allowing the tobacco industry a free rein to develop and market products. The consequence is that tobacco products are now highly addictive, palatable and appealing (e.g., with high nicotine content and added sugar and flavourings), in spite of the disastrous health consequences these impose on most users.5 6 These attributes make it difficult for people who smoke to quit and stay quit, and mean young people who experiment with smoking are much more likely to progress rapidly to regular smoking and long-term addiction.7

The proposed policy has a compelling logic; researchers and indeed the tobacco industry have long known that nicotine is the main cause of the addictiveness of smoking and that people who smoke do so mainly to obtain nicotine.8 9

“To lower nicotine too much might end up destroying the nicotine habit in a large number of consumers and prevent it from ever being acquired by new smokers.”

Quote from British American Tobacco Company internal document, June 1959 10

Several reviews and commentaries and many individual studies,1-3 11-33 have investigated the impact of very low nicotine cigarettes (VLNCs), which are generally defined as having around 0.4 mg or less nicotine per gram tobacco or per cigarette. Investigators have generally concluded that most people who smoke and who are provided with VLNCs find these cigarettes unsatisfying and as a result often cut down on the number of cigarettes they smoke, have similar or lower biomarkers of exposure to toxins, experience fewer withdrawal effects, and make more quit attempts and are more likely to successfully quit. A preliminary New Zealand study found that VLNCs without filters were less acceptable that those with filters to people who smoke34 – suggesting possible synergy with another policy proposed in the action plan – banning filters. These studies likely underestimate the impact of mandating VLNCs as the only available product, as participants usually still had access to non-VLNCs, and there is evidence of substantial non-compliance.35-37

Similar impacts have been found in marginalised groups, such as people with mental health conditions,38 where smoking prevalence is much greater. A large New Zealand trial which  investigated the impact of adding VLNCs to Quitline smoking cessation support found no difference in impact on quitting between Māori and non-Māori participants.28 Preliminary analyses of participants in the TAKe study, a cohort study of Māori people who smoke, found over half said they would quit smoking (40%) or switch to e-cigarettes (14%) if VLNCs were the only available smoked tobacco product.39 This provides further evidence for the potentially profound impact of a mandated VLNC policy. Evidence suggesting substantial impacts of VLNCs and a VLNC policy in diverse population groups suggests these interventions could reduce disparities in smoking prevalence and associated health inequities.

What is the likely impact of a VLNC policy?

Modelling studies suggest that a mandated VLNC policy would result in substantial reductions in smoking prevalence and population health gains.40 41 A historical modelling study estimated that had the tobacco industry introduced VLNCs when the health effects of smoking were established in the 1960s, millions of lives would have been saved.42

What are the arguments against this measure?

Critics have advanced three main arguments against a mandated VLNC policy.

First, they have expressed concerns that lowering the nicotine content of smoked tobacco products may result in “compensatory” smoking, where people smoke more cigarettes or puff more intensely to obtain an adequate nicotine dose.43 However, numerous studies have found that VLNCs, at worst, elicited limited “compensatory” smoking for a few days, after which people who continued smoking typically showed a sustained reduction in the number of cigarettes smoked.26 44 45 These findings are highly plausible, given neither increasing the number of cigarettes smoked nor more intensive and frequent puffing can provide an effective dose of nicotine because the levels of nicotine in VLNCs are around 25 times lower than in a standard cigarette.

Second, some commentators have argued that removing the nicotine from cigarettes amounts to prohibition or cigarettes infringes excessively on smokers’ autonomy.43  Such arguments are misplaced in a context like NZ, where harm-reduced alternative nicotine products like e-cigarettes are easily available. Rather, as over 80% of people who smoke express regret that they ever started to smoke, state they intend to quit and have tried to quit in the past,46 removing the addiction that is the major barrier to quitting will increase rather than compromise their autonomy.

Third, some suggest the proposed policies in the action plan, including mandated VLNCs, will increase the illicit and smuggled cigarette market and home grown tobacco use. Indeed, this seems to be the only argument that the tobacco industry has made against the action plan proposals. These concerns are almost certainly as exaggerated and self-serving as they have been in the past for measures like increases in tobacco taxation and standardised (plain) packs. Reviews of illicit tobacco use have noted the limited number of independent (non-tobacco industry funded) studies,47 but the most recent independent estimate from 2013 was that illicit products made up only 1.8-3.8% of the NZ market.48 Commentators have noted that any increase in illicit trade is likely to be modest and will not undermine the substantial positive effects of the policy in reducing smoking prevalence.49 Furthermore, NZ has very strong border controls and surveillance which, coupled with its relative geographical isolation, make it unlikely that smuggled tobacco will be a major problem. Nonetheless, surveillance and enforcement should be strengthened further, as the action plan proposes.

How practical is a mandated VLNC policy?

The policy has high acceptability among  people who smoke. For example, 80% of people who smoke and recent quitters expressed support for mandated VLNCs, provided alternative nicotine products are available.50 There is similar evidence of very strong support for this policy in international studies.51 52

Although no other country has yet implemented a VLNC policy, international interest in this policy measure is increasing and the evidence base continues to grow. For example,  the US FDA recently announced its intention to introduce a risk-proportionate regulatory framework for nicotine products.13 In 2018 the FDA issued an Advanced Notice of Proposed Rulemaking that recommended developing a tobacco product standard for nicotine levels in cigarettes, and that would mandate minimal or non-addictive nicotine levels.53 Recent press reports suggest introducing a mandated reduced nicotine policy for cigarettes is currently under active consideration.

The manufacture of VLNCs is technically feasible through extraction of nicotine from tobacco or use of genetically-engineered low-nicotine tobacco plants  as evidenced by the tobacco industry’s history of developing reduced nicotine products like Quest and Next and the existence of current research VLNC products (e.g. manufactured by 22nd Century Group) such as Magic and Spectrum.12

Some,22 though not all,54 studies have found that immediate reductions in nicotine content have greater positive effects than a gradual reduction in nicotine levels, so this is likely to be the preferred method of introducing the policy. Concerns tobacco companies operating in NZ may refuse to supply VLNC products and abruptly withdraw from the NZ market could be addressed by the NZ Government developing pre-implementation contracts with international producers of VLNCs that operate independently of the tobacco companies. These arrangements would enable the timely and rapid introduction of VLNCs. The 22nd Century Group has expressed its willingness to support implementation of the action plan policy by supplying VLNCs to NZ.

NZ’s regulatory framework also ensures relatively easy access to alternative nicotine-delivery products, such as e-cigarettes and pharmaceutical grade products (gum, patches etc) for people who smoke who wish to use these products to help them quit or to switch too as short or long term alternative nicotine products (if they are unable to quit nicotine use). These two policy approaches are likely to act synergistically to reduce smoking prevalence.11 55 For example, VLNCs’ impact as a cessation trigger is likely to be greater where alternative less harmful nicotine products are available for people who smoke to switch to (i.e., who cannot quit nicotine use completely).24 Concerns e-cigarettes act as a ‘gateway’ to smoking among young people would diminish if cigarettes were rendered unappealing because they no longer deliver comparable doses of nicotine to vaping products.

Finally, studies have shown many people who smoke perceive nicotine (rather than by-products of combustion) as harmful and hence may mistakenly perceive VLNCs as less harmful or alternative products like e-cigarettes as more harmful than VLNCs.50 56-58 This could deter quitting or switching to alternative, less harmful, nicotine sources, although the evidence that will eventuate is unclear.58 To address this concern prior to and during implementation it will be important to communicate to people who smoke that VLNCs are just as harmful as regular, non-VLNC, cigarettes and advise that nicotine is not the primary toxic constituent of tobacco products.

Conclusion

A mandated VLNC policy for Aotearoa NZ is a critical component of the Government’s proposed action plan which will give a realistic chance of achieving the Smokefree 2025 goal, and realising the many benefits of health improvement, enhanced equity, and cost-savings that would follow. There is a compelling logic and growing evidence base supporting this approach, and NZ can potentially draw on ongoing developments with implementation of this policy in the USA.  Robust monitoring and evaluation will be critical to assess the policy’s impact, and to ensure people who smoke are supported to quit or move to other nicotine sources. Submissions for the action plan are open. We encourage all individuals and organisations who are concerned about enhancing the health of New Zealanders and who support the need to protect future generations and help people who smoke to quit, to make submissions in support of this important measure.

 

* Author details: Richard Edwards, Janet Hoek and Nick Wilson are members of ASPIRE2025 and the Department of Public Health, University of Otago, Wellington. Chris Bullen is based at the National Institute of Health Innovation at the University of Auckland.

We acknowledge helpful comments and suggestions provided by Tracy Smith of the Dept of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA; Eric Donny of the Wake Forest School of Medicine in North Carolina, USA; and Neal Benowitz of the Center for Tobacco Control Research and Education, University of California San Francisco, San Francisco, Cal, USA.

Public Health Expert Briefing (ISSN 2816-1203)

References

  1. Benowitz NL, Henningfield JE. Reducing the nicotine content to make cigarettes less addictive. Tob Control 2013;22 Suppl 1:i14-7. doi: http://dx.doi.org/10.1136/tobaccocontrol-2012-050860
  2. Benowitz NL, Henningfield JE. Nicotine Reduction Strategy: State of the science and challenges to tobacco control policy and FDA tobacco product regulation. Prev Med 2018;117:5-7. doi: 10.1016/j.ypmed.2018.06.012 [published Online First: 2018/06/27]
  3. World Health Organization Study Group on Tobacco Regulaton. Report on the scientific basis of tobacco product regulation. Seventh report of a WHO Study Group. Geneva: World Health Organization 2019.
  4. New Zealand Parliament. Inquiry into the tobacco industry in Aotearoa and the consequences of tobacco use for Māori. Report of the Māori Affairs Select Committee. Wellington: New Zealand Parliament 2010.
  5. Blakely T, Laugesen M, Symons R, et al. New Zealand cigarettes have a high nicotine content. The New Zealand Public Health Report 1997;4(5):33-34.
  6. Hoek J, Gendall P, Eckert C, et al. Young adult susceptible non-smokers’ and smokers’ responses to capsule cigarettes. Tob Control 2019;28(5):498-505. doi: 10.1136/tobaccocontrol-2018-054470 [published Online First: 2018/10/05]
  7. Villanti AC, Collins LK, Niaura RS, et al. Menthol cigarettes and the public health standard: a systematic review. BMC Public Health 2017;17(1):983. doi: 10.1186/s12889-017-4987-z [published Online First: 2017/12/30]
  8. Bozinoff N, Le Foll B. Understanding the implications of the biobehavioral basis of nicotine addiction and its impact on the efficacy of treatment. Expert Rev Respir Med 2018;12(9):793-804. doi: 10.1080/17476348.2018.1507736 [published Online First: 2018/08/11]
  9. Prochaska JJ, Benowitz N, L. Current advances in research in treatment and recovery: Nicotine addiction. Science Advances 2019;5:eaay8763.
  10. British American Tobacco Company, RDW. Complexity of the PA 5A machine and variables pool. Minnesota Trial Exhibit 10,392, State of Minnesota et al v. Phlip Morris, Incl, et al. (1959).
  11. Benowitz NL, Donny EC, Hatsukami DK. Reduced nicotine content cigarettes, e-cigarettes and the cigarette end game. Addiction 2017;112(1):6-7. doi: 10.1111/add.13534
  12. Donny EC, Walker N, Hatsukami D, et al. Reducing the nicotine content of combusted tobacco products sold in New Zealand. Tob Control 2017(26):e37-e42. doi: 10.1136/tobaccocontrol-2016-053186
  13. Gottleib S, Zeller M. A nicotine-focused framework for public health. N Engl J Med 2017;377(12):1111-14. doi: 10.1056/NEJMp1707409 [published Online First: 2017/09/21]
  14. Hatsukam DK, Kotlyar1 M, Hertsgaard LA, et al. Reduced nicotine content cigarettes: effects on toxicant exposure, dependence and cessation. Addiction 2010;105:343-55. doi: 10.1111/j.1360-0443.2009.02780.x
  15. Hatsukami DK, Perkins KA, Lesage MG, et al. Nicotine reduction revisited: science and future directions. Tob Control 2010;19(5):e1-10. doi: 10.1136/tc.2009.035584 [published Online First: 2010/09/30]
  16. Benowitz NL, Dains KM, Hall SM, et al. Smoking behavior and exposure to tobacco toxicants during 6 months of smoking progressively reduced nicotine content cigarettes. Cancer Epidemiol Biomarkers Prev 2012;21(5):761-9. doi: 10.1158/1055-9965.EPI-11-0644
  17. Benowitz NL, Hall SM, Stewart S, et al. Nicotine and carcinogen exposure with smoking of progressively reduced nicotine content cigarette. Cancer Epidemiol Biomarkers Prev 2007;16(11):2479-85. doi: 10.1158/1055-9965.EPI-07-0393 [published Online First: 2007/11/17]
  18. Dermody SS, Donny EC, Hertsgaard LA, et al. Greater reductions in nicotine exposure while smoking very low nicotine content cigarettes predict smoking cessation. Tob Control 2015;24(6):536-9. doi: 10.1136/tobaccocontrol-2014-051797 [published Online First: 2014/09/07]
  19. Ding YS, Ward J, Hammond D, et al. Mouth-level intake of benzo[a]pyrene from reduced nicotine cigarettes. Int J Environ Res Public Health 2014;11(11):11898-914. doi: 10.3390/ijerph111111898 [published Online First: 2014/11/21]
  20. Donny EC, Denlinger RL, Tidey JW, et al. Randomized Trial of Reduced-Nicotine Standards for Cigarettes. N Engl J Med 2015;373(14):1340-9.
  21. Donny EC, Jones M. Prolonged exposure to denicotinized cigarettes with or without transdermal nicotine. Drug Alcohol Depend 2009;104(1-2):23-33. doi: 10.1016/j.drugalcdep.2009.01.021 [published Online First: 2009/05/19]
  22. Hatsukami D.K., Luo X., Jensen J.A., et al. Effect of Immediate vs Gradual Reduction in Nicotine Content of Cigarettes on Biomarkers of Smoke Exposure: A Randomized Clinical Trial. JAMA 2018;320(880-891) doi: 10.1001/jama.2018.11473
  23. Hatsukami DK, Kotlyar M, Hertsgaard LA, et al. Reduced nicotine content cigarettes: effects on toxicant exposure, dependence and cessation. Addiction 2010;105(2):343-55. doi: 10.1111/j.1360-0443.2009.02780.x
  24. Hatsukami DK, Luo X, Dick L, et al. Reduced nicotine content cigarettes and use of alternative nicotine products: exploratory trial. Addiction 2017;112(1):156-67. doi: 10.1111/add.13603
  25. McRobbie H, Przulj D, Smith KM, et al. Complementing the Standard Multicomponent Treatment for Smokers With Denicotinized Cigarettes: A Randomized Trial. Nicotine & Tobacco Research 2015;18(5):1134-41. doi: 10.1093/ntr/ntv122
  26. Smith TT, Koopmeiners JS, White CM, et al. The Impact of Exclusive Use of Very Low Nicotine Cigarettes on Compensatory Smoking: An Inpatient Crossover Clinical Trial. Cancer Epidemiol Biomarkers Prev 2020;29(4):880-86. doi: 10.1158/1055-9965.EPI-19-0963 [published Online First: 2020/02/28]
  27. Walker N, Fraser T, Howe C, et al. Abrupt nicotine reduction as an endgame policy: a randomised trial. Tob Control 2014 doi: 10.1136/tobaccocontrol-2014-051801
  28. Walker N, Howe C, Bullen C, et al. The combined effect of very low nicotine content cigarettes, used as an adjunct to usual Quitline care (nicotine replacement therapy and behavioural support), on smoking cessation: a randomized controlled trial. Addiction 2012;107(10):1857-67. doi: 10.1111/j.1360-0443.2012.03906.x
  29. Hammond D, O’Connor RJ. Reduced nicotine cigarettes: smoking behavior and biomarkers of exposure among smokers not intending to quit. Cancer Epidemiol Biomarkers Prev 2014;23(10):2032-40.
  30. Benowitz NL, Jacob P, 3rd, Herrera B. Nicotine intake and dose response when smoking reduced-nicotine content cigarettes. Clin Pharmacol Ther 2006;80(6):703-14. doi: 10.1016/j.clpt.2006.09.007 [published Online First: 2006/12/21]
  31. Benowitz NL, Nardone N, Dains KM, et al. Effect of reducing the nicotine content of cigarettes on cigarette smoking behavior and tobacco smoke toxicant exposure: 2-year follow up. Addiction 2015;110(10):1667-75. doi: 10.1111/add.12978 [published Online First: 2015/07/23]
  32. Mercincavage M, Souprountchouk V, Tang KZ, et al. A Randomized Controlled Trial of Progressively Reduced Nicotine Content Cigarettes on Smoking Behaviors, Biomarkers of Exposure, and Subjective Ratings. Cancer Epidemiol Biomarkers Prev 2016;25(7):1125-33. doi: 10.1158/1055-9965.EPI-15-1088 [published Online First: 2016/05/20]
  33. Smith TT, Koopmeiners JS, Tessier KM, et al. Randomized Trial of Low-Nicotine Cigarettes and Transdermal Nicotine. Am J Prev Med 2019;57(4):515-24. doi: 10.1016/j.amepre.2019.05.010 [published Online First: 2019/09/23]
  34. Chu J, Bullen C, Parag V, et al. Preferences for Very Low Nicotine Content Cigarettes in Smokers. Society for Research on Nicotine and Tobacco Annual Conference, Baltimore, February 22-24, 2018.
  35. Foulds J, Hobkirk A, Wasserman E, et al. Estimation of compliance with exclusive smoking of very low nicotine content cigarettes using plasma cotinine. Prev Med 2018;117:24-29. doi: 10.1016/j.ypmed.2018.04.011 [published Online First: 2018/04/08]
  36. Benowitz NL, Nardone N, Hatsukami DK, et al. Biochemical estimation of noncompliance with smoking of very low nicotine content cigarettes. Cancer Epidemiol Biomarkers Prev 2015;24(2):331-5. doi: 10.1158/1055-9965.EPI-14-1040
  37. Nardone N, Donny EC, Hatsukami DK, et al. Estimations and predictors of non-compliance in switchers to reduced nicotine content cigarettes. Addiction 2016;111(12):2208-16. doi: 10.1111/add.13519
  38. Tidey JW, Davis DR, Miller ME, et al. Modeling nicotine regulation: A review of studies in smokers with mental health conditions. Prev Med 2018;117:30-37. doi: 10.1016/j.ypmed.2018.07.003 [published Online First: 2018/10/23]
  39. Waa A, E. J. Unpublished prelimnary analysis from TAKe study. 2021
  40. Apelberg BJ, Feirman SP, Salazar E, et al. Potential Public Health Effects of Reducing Nicotine Levels in Cigarettes in the United States. N Engl J Med 2018;378:1725-33. doi: 10.1056/NEJMsr1714617
  41. Tengs TO, Ahmad S, Savage JM, et al. The AMA proposal to mandate nicotine reduction in cigarettes: a simulation of the population health impacts. Prev Med 2005;40(2):170-80. doi: 10.1016/j.ypmed.2004.05.017 [published Online First: 2004/11/10]
  42. Levy DT, Cummings KM, Heckman BW, et al. The Public Health Gains Had Cigarette Companies Chosen to Sell Very Low Nicotine Cigarettes. Nicotine Tob Res 2021;23(3):438-46. doi: 10.1093/ntr/ntaa128 [published Online First: 2020/07/28]
  43. Bates C. Taking the nicotine out of cigarettes : why it is a bad idea / Clive Bates. Bulletin of the World Health Organization : the International Journal of Public Health 2000 ; 78(7) : 944 2000
  44. Benowitz NL, Donny EC, Edwards KC, et al. The Role of Compensation in Nicotine Reduction. Nicotine Tob Res 2019;21(Suppl 1):S16-S18. doi: 10.1093/ntr/ntz120 [published Online First: 2019/12/24]
  45. Smith TT, Koopmeiners JS, Hatsukami DK, et al. Mouth-Level Nicotine Intake Estimates from Discarded Filter Butts to Examine Compensatory Smoking in Low Nicotine Cigarettes. Cancer Epidemiol Biomarkers Prev 2020;29(3):643-49. doi: 10.1158/1055-9965.EPI-19-0905 [published Online First: 2020/02/28]
  46. Edwards R. Unpublished data from the 2018 New Zealand ITC study. https://www.otago.ac.nz/wellington/departments/publichealth/research/otago022619.html.
  47. Ernst and Young. Evaluation of the tobacco excise increases – Final Report – 27 November 2018. Wellington: Ministry of Health 2018.
  48. Ajmal A, Veng Ian U. Tobacco tax and the illicit trade in tobacco products in New Zealand. Aust N Z J Public Health 2015;39(2):116-20. doi: 10.1111/1753-6405.12389
  49. Lindblom EN. Illicit Trade Poses No Threat to an FDA Rule to Minimize Nicotine in Smoked Tobacco Products. Am J Public Health 2019;109(7):960-61. doi: 10.2105/AJPH.2019.305138 [published Online First: 2019/06/06]
  50. McKiernan A, Stanley J, Waa AM, et al. Beliefs among Adult Smokers and Quitters about Nicotine and De-nicotinized Cigarettes in the 2016-17 ITC New Zealand Survey. Tobacco Regulatory Science 2019;5(5):400-09. doi: 10.18001/trs.5.5.1
  51. Chung-Hall J, Fong GT, Driezen P, et al. Smokers’ support for tobacco endgame measures in Canada: findings from the 2016 International Tobacco Control Smoking and Vaping Survey. CMAJ Open 2018;6(3):E412-E22. doi: 10.9778/cmajo.20180025 [published Online First: 2018/09/30]
  52. Bolcic-Jankovic D, Biener L. Public opinion about FDA regulation of menthol and nicotine. Tob Control 2015;24(e4):e241-5. doi: 10.1136/tobaccocontrol-2013-051392 [published Online First: 2014/03/19]
  53. Food and Drug Administration. Tobacco Product Standard for Nicotine Level of Combusted Cigarettes 2018. Available at: https://www.federalregister.gov/documents/2018/03/16/2018-05345/tobacco-productstandard-for-nicotine-level-of-combusted-cigarettes.
  54. Hatsukami DK, Donny EC, Koopmeiners JS, et al. Compensatory smoking from gradual and immediate reduction in cigarette nicotine content. Cancer Epidemiology, Biomarkers & Prevention 2015;24(2):472–76.
  55. Smith TT, Hatsukami DK, Benowitz NL, et al. Whether to push or pull? Nicotine reduction and non-combusted alternatives – Two strategies for reducing smoking and improving public health. Prev Med 2018;117:8-14. doi: 10.1016/j.ypmed.2018.03.021 [published Online First: 2018/04/01]
  56. Byron MJ, Hall MG, King JL, et al. Reducing Nicotine Without Misleading the Public: Descriptions of Cigarette Nicotine Level and Accuracy of Perceptions About Nicotine Content, Addictiveness, and Risk. Nicotine Tob Res 2019;21(Suppl 1):S101-S07. doi: 10.1093/ntr/ntz161 [published Online First: 2019/12/24]
  57. Denlinger-Apte RL, Cassidy RN, Colby SM, et al. Effects of Cigarette Nicotine Content and Menthol Preference on Perceived Health Risks, Subjective Ratings, and Carbon Monoxide Exposure Among Adolescent Smokers. Nicotine Tob Res 2019;21(Suppl 1):S56-S62. doi: 10.1093/ntr/ntz127 [published Online First: 2019/12/24]
  58. Pacek LR, Joseph McClernon F, Denlinger-Apte RL, et al. Perceived nicotine content of reduced nicotine content cigarettes is a correlate of perceived health risks. Tob Control 2018;27(4):420-26. doi: 10.1136/tobaccocontrol-2017-053689 [published Online First: 2017/07/25

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